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The aim of this work is to evaluate in vivo the anti-inflammatory effect of creams containing kaurenoic acid (KA), isolated from the acetonic extract of the W. paludosa (stems and roots). The herbal drug was incorporated...

This study evaluated the effect of Cordia verbenacea essential oil (CV) and glycolic acid 70 % (GA), isolated and associated, on Wistar rats back skin. A base gel was added to 2 % of CV and/or 10 % of GA, thus forming ...

The objective of the present investigation was to develop and evaluate microemulsion-based hydrogel (MBH) for the topical delivery of sinomenium. The solubility of sinomenium in oils and surfactants was evaluated to iden...

The objective was to develop and validate a method for the determination of total polyphenols in a vaginal gel containing a dried extract of Aroeira (Schinus terebinthifolius Raddi). The method was developed by UV spectr...

D-002 (beeswax alcohols) contains triacontanol as most abundant component. Local application of triacontanol has been shown anti-inflammatory effects on chemically-induced dermatitis and oral treatment with D-002 produce...

Nanoemulsions are special emulsions that consist in a very small drop with sizes between 20 to 500 nm. When they are intended for topical application, the main problem of nanoemulsions is their low viscosity, which is re...

Niosomes have been reported as a possible approach to improve the low skin penetration and bioavailability characteristics shown by conventional topical vehicle for Baclofen (centrally acting skeletal muscle relaxant)....

Non-irritant, non-comedogenic and non-polar emollients were pre-selected for determinations of relative dielectric permittivity and solubility of benzoyl peroxide (BP). Those solvents capable of solubilizing BP in concen...

The present study involves development and investigation of liposomal system for improving skin residence of ciclopirox olamine in cutaneous mycosis. Spherical unilamellar liposomes of ciclopirox olamine were prepared ...

Hydroquinone (HQ) is a drug reported to possess manifold biological activities. HQ is highly unstable into various topical vehicles, presenting low topical bioavailability and a relevant level of toxicity. The Pluronic®...

The effects of the crude extract and fractions of Cayaponia podantha (Cp) on experimental inflammation models were investigated. Paw edema induced by carrageenan (Cg) and peritonitis induced by Cg, LPS, and LTB4 were eva...

The aim of the present study was to evaluate the antimicrobial and cytotoxic activity of the ethanolic extract of S. cumini according to the Clinical and Laboratory Standards Institute reference method (with modification...

O objetivo deste trabalho foi avaliar a atividade anitinflamatória tópica in vivo do extrato aquoso e frações do fruto de Cayaponia cabocla (Vell.) Mart. (Curcubitaceae). Extratos e frações dos frutos frescos de C....

Studies to evaluate the clinical efficacy and safety of various topical NSAIDS compared to oral NSAIDS have been reported but little research has been conducted to evaluate the efficacy of topical NSAIDS from different m...

La papaína es una enzima proteolítica usada en formulaciones tópicas para el tratamiento de quemaduras, heridas, cicatrices, exfoliación de la piel mediante depilado, así como agente depilatorio progresivo y para in...

Nanocapsule suspensions containing coenzyme Q10 were prepared by interfacial deposition. The nanocapsules showed characteristics compatible with dermal application: slightly acid pH, drug content close to 100%, particle ...

The purpose of the present investigation was to evaluate 6-O-palmitoyl ascorbic acid (ASC16) and 6-O-lauril ascorbic acid (ASC12) for their capacity to promote permeation of Ibuprofen (IBU) through hairless mouse skin in...

Se reportan las actividades citotóxicas de neolignanos del tipo 8.0.4', arilpropanoides y compuestos estructuralmente relacionados. Aquellos compuestos que poseen una fuerte actividad antifúngica presentaran paralelame...

In this work the effects of topic use of Brazilian green propolis gel in the contraction of wounds performed in rat s skin was evaluated. In ten female Wistar rats were done four wounds in dorsal region. Two wounds in ea...

The aim of this study was to develop topical hydrogels containing diclofenac potassium (DP) at 1 % w/v concentration using conventional hydrophilic hydroxypropyl methyl cellulose (HPMC, 50cPs) and modified hydrophobic ...

Recientemente fue demostrado que formulaciones tópicas que contienen quercetina inhibieron la tensión oxidante y la inflamación cutánea inducida por la radiación UVB. No obstante, no fue aún investigada la fotoesta...

Xylitol is a widely studied sugar with therapeutic properties and is effective against microorganisms. Despite a variety of toxicological data being available about this compound, dermal toxicological tests cannot be fou...

Inhibition action of propylene glycol (PG) on the antifungal activity of fluconazole has been investigated. PG was used as cosolvent and penetration enhancer in different solutions and topical dosage forms. The interacti...

Pediculosis is a worldwide head infestation caused by Pediculus humanus. The treatment for this infestation is use of topical insecticides and there are studies which show that the insect may be resistant to chemical act...