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116 resultados encontrados.

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Evaluation of possible adverse effects in broiler chickens supplemented with ibuprofen or meloxicam
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Evaluation of possible adverse effects in broiler chickens supplemented with ibuprofen or meloxicam
E.R.M. Almeida et al · Universidade Federal de Minas Gerais, Escola de Veterinária · 2025 · ISSN 1678-4162
ABSTRACT Antimicrobial Growth Promoters (AGPs) have been phased out due to their link to antibiotic resistance. While their exact mode of action remains unknown, they are thought to reduce inflammation in the gut. This s...
LCC LCC:Animal cultureIdioma eng
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Improving paclitaxel delivery: Liposomal encapsulation for enhanced solubility, stability and targeted therapy
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Improving paclitaxel delivery: Liposomal encapsulation for enhanced solubility, stability and targeted therapy
Muhammad Awais Shahid et al · AMMANIF · 2024 · ISSN 2521-0521
Background: Paclitaxel, a potent anti-neoplastic agent, finds application in treating various malignancies like breast, ovarian, lung, and pancreatic cancers. However, paclitaxel's hydrophobicity renders it poorly solubl...
LCC TENDOlBoYXJtYWN5IGFuZCBtYXRlcmlhIG1lZGljYQ~~Idioma eng
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Investigation and etiological detection of a foodborne disease outbreak caused by Vibrio parahaemolyticus in Nantong City
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Investigation and etiological detection of a foodborne disease outbreak caused by Vibrio parahaemolyticus in Nantong City
SHUAI Xiaobo et al · The Editorial Office of Chinese Journal of Food Hygiene · 2025 · ISSN 1004-8456
ObjectiveTo systematically investigate a foodborne disease outbreak caused by Vibrio parahaemolyticus （V. parahaemolyticus） in Nantong City through epidemiological investigation， laboratory testing， whole-genome ...
LCC TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~; LCC:Nutrition. Foods and food supplyIdioma zho
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Microneedle-based injection of Fungizone/Amphotericin B: an effective treatment for American cutaneous leishmaniasis in mice
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Microneedle-based injection of Fungizone/Amphotericin B: an effective treatment for American cutaneous leishmaniasis in mice
Ryan H. Huston et al · Taylor & Francis Group · 2026 · ISSN 1071-7544
Amphotericin B (AmB) is a potent, accessible, FDA-approved drug against CL with damaging side effects. While newer lipid formulations have less toxicity, limitations include affordability and cold-chain requirements. CL ...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Optimization of individualized therapy with oral valproic acid in pediatric patients with epilepsy based on factors influencing blood concentrations
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Optimization of individualized therapy with oral valproic acid in pediatric patients with epilepsy based on factors influencing blood concentrations
Yinhui Qin et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
BackgroundValproic acid (VPA) is widely used in pediatric epilepsy, but its blood concentrations vary considerably among pediatric patients with epilepsy. This study aimed to investigate the factors influencing VPA blood...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Reframing small cell lung cancer: therapeutic lessons from hematologic malignancies
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Reframing small cell lung cancer: therapeutic lessons from hematologic malignancies
Kanak Parmar et al · Frontiers Media S.A · 2026 · ISSN 2234-943X
Small cell lung cancer (SCLC) remains one of the most aggressive malignancies, characterized by rapid proliferation, early metastatic dissemination, and poor long-term survival despite initial sensitivity to therapy. SCL...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Resistance and efficiency of amikacin in critically ill septic children: a cross-sectional study
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Resistance and efficiency of amikacin in critically ill septic children: a cross-sectional study
Aya Osama Mohamed et al · Hygeia Press di Corridori Marinella · 2026 · ISSN 2281-0692
Background: Therapeutic drug monitoring facilitates the individualiza­tion of amikacin dosing for patients based on pharmacodynamics and pharmacokinetics. Its efficacy is measured by peak serum concentration (Cpeak) / m...
LCC LCC:Medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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Therapeutic potential of hesperidin methyl chalcone in the experimental treatment of cutaneous leishmaniasis
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Therapeutic potential of hesperidin methyl chalcone in the experimental treatment of cutaneous leishmaniasis
Anny Maíza Vargas BRASIL et al · Instituto Nacional de Pesquisas da Amazônia · 2024 · ISSN 0044-5967
ABSTRACT Drug repositioning seeks to discover new applications for a drug that has already been approved in the market, resulting in faster and lower cost solutions, generally used for diseases that receive little invest...
LCC LCC:Science (General)Idioma eng
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Cytotoxicity Study of Plantago major L. Extracts on RAW 264.7 Macrophages
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Cytotoxicity Study of Plantago major L. Extracts on RAW 264.7 Macrophages
Ahmad Marzuki et al · Universitas Gadjah Mada · 2025 · ISSN 1410-5918
The use of medicinal plants in modern medicine is on the rise, particularly in addressing diabetes and its associated complications, such as persistent inflammatory wounds. Plantago major L. (P. major) is known for its r...
LCC LCC:MedicineIdioma eng
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How to efficiently establish animal models of cholangiocarcinoma: challenges and inspiration
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How to efficiently establish animal models of cholangiocarcinoma: challenges and inspiration
Gou Ruiqiang et al · De Gruyter · 2026 · ISSN 2749-9642
Cholangiocarcinoma (CCA) consists of a class of malignant tumors of the biliary system, with a rising incidence and carries a poor prognosis. Developing reliable animal models of CCA is crucial to elucidate the pathogene...
LCC LCC:MedicineIdioma eng
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A 13-gene prognostic model developed using machine learning to predict the response to neoadjuvant chemoradiotherapy in rectal carcinoma
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A 13-gene prognostic model developed using machine learning to predict the response to neoadjuvant chemoradiotherapy in rectal carcinoma
Zhanhua Gao et al · BMC · 2026 · ISSN 1475-2867
Abstract Backgrounds Neoadjuvant chemoradiation (nCRT) is a standard treatment for rectal carcinoma that reduces tumor size and local recurrence while improving the rate of sphincter preservation. However, many patients ...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~; LCC:CytologyIdioma eng
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Activity of Anti-MRSA Quinolone, Levonadifloxacin Against Gram Positive Cocci Obtained from Clinical Samples in a Tertiary Care Center in Western India
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Activity of Anti-MRSA Quinolone, Levonadifloxacin Against Gram Positive Cocci Obtained from Clinical Samples in a Tertiary Care Center in Western India
Aishwarya Babu et al · Dr. Annil Mahajan · 2026 · ISSN 0972-1177
Background: Gram-positive cocci, including Staphylococcus aureus, Enterococcus species, and coagulase-negative Staphylococcus species (CONS), are major causes of nosocomial infections. The increasing prevalence of drug-r...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~; LCC:Internal medicineIdioma eng
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Alitretinoin in treatment of chronic hand eczema – mechanism of action
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Alitretinoin in treatment of chronic hand eczema – mechanism of action
Maria Matejko et al · Termedia Publishing House · 2016 · ISSN 0033-2526
Hand eczema is a common skin disorder with significant functional and economic impacts. Conventional therapy options, such as topical corticosteroids, calcineurin inhibitors, phototherapy and systemic immunosuppressants,...
LCC LCC:Medicine; LCC:DermatologyIdioma eng
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Anti-psoriatic and Anti-inflammatory Potentials of Phytochemicals from Curcuma longa against Interleukin-17A and Inducible Nitric Oxide Synthase: An In Silico Study
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Anti-psoriatic and Anti-inflammatory Potentials of Phytochemicals from Curcuma longa against Interleukin-17A and Inducible Nitric Oxide Synthase: An In Silico Study
Misbaudeen Abdul-Hammed et al · Universitas Gadjah Mada · 2024 · ISSN 1410-5918
LCC LCC:MedicineIdioma eng
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Anticancer Synergy of Myricetin and Doxorubicin in Breast Cancer: Network Pharmacology and In Vitro Evaluation
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Anticancer Synergy of Myricetin and Doxorubicin in Breast Cancer: Network Pharmacology and In Vitro Evaluation
Roihatul Mutiah et al · Universitas Gadjah Mada · 2026 · ISSN 1410-5918
Breast cancer is a major public health problem worldwide, leading to an urgent need for the development of new strategies to improve treatment efficacy and manage drug resistance. Doxorubicin is among the most commonly u...
LCC LCC:MedicineIdioma eng
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Artificial Intelligence and Prostate–Breast Cancer Biology: Recent Advances in Treatments and Perspectives — A Comprehensive Review
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Artificial Intelligence and Prostate–Breast Cancer Biology: Recent Advances in Treatments and Perspectives — A Comprehensive Review
Russell B. O. Ouma et al · Wiley · 2026 · ISSN 2398-8835
ABSTRACT Background and Aims The therapeutic limitations of conventional cancer treatment currently deployed are driving the development and creation of new nano‐drugs. Prostate cancer (PCa) is a prevalent clinical pro...
LCC LCC:MedicineIdioma eng
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Chlorogenic acid and gallic acid synergistically reduce hyperglycemia and hyperlipidemia in diabetic BALB/c mice
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Chlorogenic acid and gallic acid synergistically reduce hyperglycemia and hyperlipidemia in diabetic BALB/c mice
Mudassir Hassan et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Given the multifactorial nature of diabetes and limitations of conventional monotherapies, combination therapies involving natural bioactive compounds offer a complementary strategy for more effective management...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Comparison of the diagnostic value of targeted next-generation sequencing, metagenomic next-generation sequencing, and Xpert MTB/RIF in adult pulmonary tuberculosis
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Comparison of the diagnostic value of targeted next-generation sequencing, metagenomic next-generation sequencing, and Xpert MTB/RIF in adult pulmonary tuberculosis
Qiaoqian Chen et al · BMC · 2026 · ISSN 1471-2334
Abstract Tuberculosis (TB) has high morbidity and mortality rates, and drug-resistant strains pose an increasing challenge. Traditional methods for detecting the Mycobacterium tuberculosis complex (MTBC) are insufficient...
LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng
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Cost-effectiveness analysis of neoadjuvant docetaxel plus androgen deprivation therapy before radical prostatectomy in high-risk localized prostate cancer
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Cost-effectiveness analysis of neoadjuvant docetaxel plus androgen deprivation therapy before radical prostatectomy in high-risk localized prostate cancer
Qi Liu et al · Frontiers Media S.A · 2026 · ISSN 2296-2565
ObjectiveHigh-risk localized prostate cancer is often associated with a higher risk of disease progression post-surgery. While radical prostatectomy (RP) is a cornerstone treatment, neoadjuvant chemohormonal therapy (CHT...
LCC LCC:Public aspects of medicineIdioma eng
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Current Approaches to the Treatment of Hepatitis C Virus Infection in Chronic Kidney Disease
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Current Approaches to the Treatment of Hepatitis C Virus Infection in Chronic Kidney Disease
Ayşegül ORUÇ et al · Turkish Society of Nephrology · 2019 · ISSN 2667-4440
Hepatitis C virus (HCV) infection in patients with chronic kidney disease (CKD) is a major cause of morbidity and mortality. HCV infection is associated with some glomerular disease. It also has a high incidence in patie...
LCC LCC:Internal medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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Development and characterization of diacerein cream with curcuma longa having potent anti-inflammatory effect
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Development and characterization of diacerein cream with curcuma longa having potent anti-inflammatory effect
Muhammad Razi Ullah Khan · AMMANIF · 2024 · ISSN 2521-0521
Objective: Osteoarthritis, the most common type of arthritis, affects an increasing number of people and greatly diminishes their quality of life. Treatments for Osteoarthritis are divided into two categories: NSAIDs, wh...
LCC TENDOlBoYXJtYWN5IGFuZCBtYXRlcmlhIG1lZGljYQ~~Idioma eng
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Development of hesperidin loaded lipid-chitosan nanoparticles: physicochemical characterization, molecular docking and ex vivo study
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Development of hesperidin loaded lipid-chitosan nanoparticles: physicochemical characterization, molecular docking and ex vivo study
Sadaf Jamal Gilani et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Hesperidin (HSP) is a bioactive flavonoid, and its activity is limited due to poor water solubility. We designed this research to develop and evaluate hesperidin nanoparticles (HSPNPs) to enhance drug release an...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Development of ready-to-use tranexamic acid gauze as a hemostatic material for oral surgery: fabrication, hemostasis, and shelf-life
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Development of ready-to-use tranexamic acid gauze as a hemostatic material for oral surgery: fabrication, hemostasis, and shelf-life
Taechana Sitthikornvanich et al · BMC · 2026 · ISSN 1472-6831
Abstract Background Postoperative hemorrhage is one of the major complications of oral surgery. Conventional hemostatic methods, such as chair-side preparation of tranexamic acid (TXA)-soaked gauze or TXA mouthwash, ofte...
LCC TENDOkRlbnRpc3RyeQ~~Idioma eng
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Effectiveness of interpersonal psychotherapy in comparison to other psychological and pharmacological interventions for reducing depressive symptoms in women diagnosed with postpartum depression in low‐ and middle‐income countries: A systematic review
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Effectiveness of interpersonal psychotherapy in comparison to other psychological and pharmacological interventions for reducing depressive symptoms in women diagnosed with postpartum depression in low‐ and middle‐income countries: A systematic review
Harmeet Kaur Kang et al · SAGE Publishing · 2024 · ISSN 1891-1803
Abstract Background Postpartum depression (PPD) is a condition that can affect any woman regardless of ethnicity, age, party, marital status, income, and type of delivery. This condition is highly prevalent worldwide. PP...
LCC TENDOlNvY2lhbCBTY2llbmNlcw~~Idioma eng
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