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Background: The use of synthetic antihelminthic agents is often associated with adverse side effects and increasing drug resistance. These challenges have intensified the search for safer and more effective plant-based ...

Objective: To present the first systematic review on the empirical evidence for variations in intraindividual pain intensity in patients with long-term pain conditions. Methods: The search was conducted on Medline and in...

Lysosomal dysfunction is a core pathological driver of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Transcription factor EB (TFEB) serves as a master regulator of lysosomal biogenesis, and its ...

Chlamydia psittaci is an obligate intracellular pathogen that poses a significant threat to both human and animal health. The current therapeutic strategies are limited by the emergence of potential drug resistance, unde...

We report a rare case of 32-year-old female with malignant reninoma complicated by pulmonary metastasis and ATRX mutation (p.G1964*, VAF 23.73%), initially misdiagnosed as renal pelvic carcinoma and treated with radical ...

Aortic diseases (aortic aneurysm, aortic dissection, atherosclerosis) represent a substantial clinical and economic burden due to the lack of effective early diagnostic tools and mechanism-based therapies. Metabolomics, ...

Introduction: Ketamine is a widely used intravenous dissociative anaesthetic and analgesic agent with a high safety profile. Increasingly, it is being used as a recreational drug for its hallucinogenic properties. Chroni...

Resumen: La nutrición en pacientes con cáncer es un tema de gran interés, ya que el cáncer es la segunda causa principal de muerte en todo el mundo y la principal causa de muerte en Chile. En pacientes con cáncer, e...

Abstract The aim of this study was to verify that substance use among adolescents would be linked to perceptions of freedom in leisure. It was selected for convenience sampling 186 adolescents at Projeto Quixote in a pub...

Introduction: Crack cocaine use is associated with polydrug abuse, and inpatients dependent on crack exhibit profiles of serious consumption patterns. Use of alcohol and tobacco and other drugs is a risk factor for exper...

Background: Cuproptosis, a copper-dependent form of programmed cell death, has been implicated in the progression of various cancers. However, the role of LOXL2 - a cuproptosis-related gene (CRG) - and its prognostic val...

This protocol outlines planned methodology for a systematic review and meta-analysis of dopaminergic neuroimaging findings in individuals with opioid use disorder (OUD). Converging evidence across substance use disorders...

Through cell-based screening models, we have identified a new compound IMB5043, a thiophenylated pyridazinone, which exerted cytotoxicity against cancer cells. In the present study, we evaluated its antitumor efficacy an...

Escherichia coli is the most common causative agent of urinary tract infections (UTIs). Important virulence factors are the FimH and PapGII adhesion genes. The current work sought to ascertain the prevalence of the fimH ...

The relentless pursuit of athletic excellence is shadowed by the equally persistent evolution of performance-enhancing drugs (PEDs). In recent years, the antidoping landscape has been profoundly shaped by the rise of two...

Background: Febrile illness in pediatric populations often poses a diagnostic challenge due to overlapping clinical features across various etiologies. While respiratory infections are common, urinary tract infections (U...

IntroductionEarly identification of adolescents at risk for substance use is critical for timely intervention. However, standard screening tools like CRAFFT (Car, Relax, Alone, Forget, Family and Friends, Trouble) and S2...

In the present study, the influence of polymeric concentration, its blend and drug loading dose on the in vitro drug release pattern of alfuzosin hydrochloride from its transdermal patches has been investigated. Ratio ...

The elderly population and the incidence of chronic diseases are growing rapidly in Brazil. This raises the demand for health services (like Nursing Homes - NH) and drugs, exposing this population to Potential Drug Thera...

Se reporta el hallazgo de "Éxtasis"(MDMA)y de "Love Drug'(MDA) en una muestra de orina llegada para un análisis rutinario de drogas de abuso. Se practicaron ensayos de orientación inmunológicos "AMIA", "ELISA" y "Dru...

Inflammatory diseases including different types of rheumatic diseases are very common throughout the world. The greatest disadvantage in the presently available potent synthetic drugs lies in their side effects, toxicity...

Richardia brasiliensis é uma planta utilizada na medicina popular como expectorante, emética, diaforética, vermífuga e no tratamento de hemorróidas. O objetivo desse trabalho foi obter parâmetros de controle de qua...

The high incidence of diarrhea in the population demands a search for new therapeutic options and easy access, mainly from plant-based sources. Leaves and bark of Guazuma ulmifolia Lam. (Sterculiaceae) are popularly empl...

El tratamiento farmacológico tradicional de la epilepsia está orientado al control de las convulsiones que caracterizan las crisis epilépticas. En contraste, las investigaciones más recientes ponen énfasis en la com...