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Abstract Immunotherapy serves as the fourth modality for cancer treatment, following surgery, radiotherapy, and chemotherapy. However, its efficacy remains inconsistent due to the heterogeneity of the tumor microenvironm...

Abstract Dormant cancer cells are a significant source of cancer recurrence and metastasis and exhibit robust resistance to conventional therapies. Therefore, the exploration of novel therapeutic strategies to eliminate ...

Abstract Theileriosis, a tick-borne disease caused by apicomplexan parasites of the genus Theileria, poses a major constraint to livestock productivity worldwide. Existing chemotherapeutics are increasingly limited by ho...

Abstract Alzheimer’s disease (AD) is a prevalent and progressive neurodegenerative disease characterized by behavioral abnormalities, memory loss, and cognitive decline, presenting significant challenges for early diag...

Abstract Background Patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) who failed bispecific antibody (BsAb) therapy face an extremely poor prognosis, necessitating exploration of effective salva...

Abstract Scavenging excess reactive oxygen species (ROS) and positively improving intestinal dysbiosis is a promising therapeutic strategy for alleviating inflammatory bowel disease (IBD). However, conventional clinical ...

Abstract Breast cancer remains one of the most prevalent malignant tumors affecting women worldwide and continues posing a major threat to global health. Current clinical treatments include surgery, chemotherapy, radioth...

Abstract Background Lupus nephritis (LN) is a common and severe manifestation of systemic lupus erythematosus (SLE). We sought to evaluate treatment patterns, treat-to-target state attainment, and outcomes of patients wi...

Abstract Purpose Intraoperative radiotherapy (IORT) is designed to deliver a precise dose of ionizing radiation to a tumor or tumor bed after surgical resection. The IORT procedure can deliver targeted radiation to the t...

Abstract Background Staphylococcus aureus skin infections represent a persistent clinical challenge owing to their high pathogenicity, multidrug resistance, and biofilm-associated recurrence, which collectively impair an...

Abstract Background Estrogen receptor alpha (ERα)-positive luminal breast cancer is commonly treated with aromatase inhibitors (AI) to block estrogen signaling; however, resistance frequently develops, limiting therapy ...

Abstract Background Occupational therapy practices are expanding in Turkey; however, pediatric professionals lack validated, client-centered assessment instruments for children with attention-deficit/hyperactivity disord...

Abstract Background Chikungunya virus (CHIKV) infection can progress to severe clinical forms requiring intensive care. This study aimed to characterize adult patients admitted to intensive care units (ICUs) with CHIKV d...

Abstract Background Strict postoperative blood pressure (BP) control within a narrow range is crucial after Carotid Endarterectomy (CEA) to minimize risks like stroke and hyperperfusion syndrome. Our institution targets ...

Abstract Background The role of inflammation-induced myeloid-biased hematopoiesis in driving resistance to immune checkpoint blockade (ICB) is recognized, yet the intricate mechanisms through which tumors orchestrate it ...

Abstract Background Infections caused by members of the Mycobacterium fortuitum complex are generally mild and confined to skin and soft tissues, while severe disease in immunocompetent individuals is uncommon. Within th...

Abstract Juvenile idiopathic arthritis (JIA) comprises a heterogeneous group of childhood-onset inflammatory arthritides that remain challenging to treat. An expanding range of biologic and targeted synthetic disease-mod...

Abstract Background The dysfunction of osteoblasts has been identified as a pivotal contributor to bone erosion in rheumatoid arthritis (RA). Emerging evidence shows long non-coding RNAs (lncRNAs) as important regulators...