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The pharmacokinetics of lansoprazole after a single intravenous dose of 30 mg was determined in 10 healthy volunteers and 10 peptic ulcers patients. In this work, a liquid-liquid extraction and enrichment method with RP-...

Diabetes mellitus (DM) is a serious health problem affecting millions of individuals worldwide. It is showed that some changes of many enzymes and transporters concerned with metabolism and disposal of drug have taken ...

Gastric ulcer is one of ulcerous diseases and may result in some changes of many enzymes and transporters concerned with metabolism and disposal of drug. The pharmacokinetic of drug should be different between peptic ulc...

A highly sensitive liquid chromatographic tandem mass spectrometric (LC-MS/MS) method for determination of dextromethorphan in rabbit plasma using triazolam as the internal standard (IS) was developed. Plasma samples wer...

A simple, rapid, sensitive and selective method of high-performance liquid chromatography with fluorescence detection was developed for determination of puerarin in rat plasma. Chromatography was carried out on a reverse...

HPLC-DAD was used and validated for the simultaneous determination of five flavonoids (rutin, quercitrin, quercetin, kaempferol and isorahamnetin) in rabbit plasma. Chromatographic separation was performed on an Aglient ...

The oral bioavailability of genistein (GE) in its benzensulfonates was studied in search for new drugs or food functional ingredients. The plasma were collected at different points of time after the intragastric or intra...

Semen Persicae was a traditional Chinese medicine for the treatment of diseases such as inflammation and hyperlipemia. Amygdalin was one of the main active ingredients of this traditional Chinese medicine. In this paper,...

The objective of the present study was to investigate the applicability of matrix type chitosan treated alginate multiple unit systems (MUS) for sustained release of metronidazole prepared by ionotropic gelation method. ...

A LC-MS method was developed and validated for simultaneous determination of 6, 7-di-hydroxyligustilide and gastrodin in rat plasma, and which was subsequently applied in the pharmacokinetic analysis of an administration...

Se presentan dos nuevos métodos de cálculo de parámetros farmacocinéticos para fámacos que administrados por vía extravacular se comportan según el modelo de un compartimiento con cinética lineal. Ambos son aprop...

En el presente trabajo se determinaron, en bovinos lecheros en lactancia, los modelos y parámetros farmacocinéticos y la penetración en leche de ceftazidima. Se utilizaron 5 bovinos lecheros sanos, con una producción...

In this study, matrix type patch formulations of flurbiprofen using certain skin permeation enhancers [isopropyl myristate (IPM), isopropyl palmitate (IPP) and Tween 80] were formulated, evaluated and compared. The cum...

Repaglinide (RGL) loaded polymeric drug delivery devices like microcapsules (MC) and transdermal patches (TDP) were formulated and there in vitro-in vivo parameters compared to find out the best route of drug delivery. T...

Los macrólidos son un grupo de antibacterianos caracterizados por la presencia de un anillo lactona macrocíclico como núcleo de su estructura química. Son agentes bacteriostáticos, aunque en determinados casos puede...

Las soluciones farmacocinéticas del tipo "modelo abierto de un compartimiento" han sido ampliamente estudiadas; sin embargo la mayoría de los métodos aproximados presentan dificultades cuando las constantes de elimina...

The aim of this study was to evaluate the in vivo behavior of matrix tablets formulated with ketoprofen as a model drug after oral administrations in healthy Malaysian male volunteers and to compare its rate and extent o...

A double-center, open-label, two-way crossover study was conducted in 24 healthy volunteers to assess the bioequivalence of a combined lamivudine/zidovudine tablet related to a reference and test drug products. The volun...

El presente trabajo tuvo por objeto diseñar y elaborar comprimidos de ácido acetilsalicílico (AAS) de administración sublingual con una baja concentración de principio activo que preserve la actividad antigagregante...

Los medicamentos genéricos de calidad y bajo costo están disponibles para la población brasilera desde 1999, cuando se instituyó la Política de Medicamentos Genéricos de Brasil. Este artículo presenta los criterio...

Las variaciones en la biodisponibilidad, junto con la falta de equivalencia entre los medicamentos producidos por distintos laboratorios, constituyen uno de los problemas más importantes en el control biofarmacéutico d...

El presente trabajo reporta el estudio de la farmacocinética del paracetamol en ratas (100 mg/kg, p.o) con flujo biliar modificado, interrumpido por canulación del conducto biliar o estimulado por acción farmacológic...