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100 resultados encontrados.

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Leonurine: A Multifaceted Bioactive Alkaloid—From Pharmacological Mechanisms to Clinical Translation: A Narrative Review
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Leonurine: A Multifaceted Bioactive Alkaloid—From Pharmacological Mechanisms to Clinical Translation: A Narrative Review
Zhouyue Gu · Wiley · 2026 · ISSN 2398-8835
ABSTRACT Background Leonurine (LEO), a bioactive alkaloid derived from the Leonurus genus, exhibits diverse pharmacological activities including uterotonic, antioxidant, anti‐inflammatory, antiapoptotic, Antitumor, and...
LCC LCC:MedicineIdioma eng
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The preclinical evidence and clinical translational prospects of medicarpin
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The preclinical evidence and clinical translational prospects of medicarpin
Lingjie Kong et al · Elsevier · 2026 · ISSN 1096-1186
Medicarpin (MED) is an isoflavonoid compound derived from traditional Chinese medicine (TCM). Numerous preliminary experimental studies have shown that MED has significant pharmacological effects in the treatment of canc...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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The regulatory mechanism of NLRP3 inflammasome in the “immune paralytic-overactivation” imbalance in sepsis: the latest progress from molecular signaling to clinical translation
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The regulatory mechanism of NLRP3 inflammasome in the “immune paralytic-overactivation” imbalance in sepsis: the latest progress from molecular signaling to clinical translation
Gaosheng Zhou et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
Sepsis remains a major challenge in critical care medicine worldwide, characterized by a dynamic imbalance of the immune system between two extremes: “immunoparalysis” and “hyperactivation.” This dysregulation se...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Recent advances in TGF-β signaling: insights into regulation, pathophysiological function, and clinical translation
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Recent advances in TGF-β signaling: insights into regulation, pathophysiological function, and clinical translation
Xiaohua Yan et al · SpringerOpen · 2026 · ISSN 2045-9769
Abstract Cytokines from the transforming growth factor-β (TGF-β) superfamily are essential regulators of cell growth, survival, and differentiation, playing a pivotal role in mammalian embryonic development, adult tiss...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~; LCC:Biology (General)Idioma eng
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Limitations in the clinical translation of mesenchymal stromal cells: standardisation, heterogeneity and the recipient
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Limitations in the clinical translation of mesenchymal stromal cells: standardisation, heterogeneity and the recipient
Anna Etzenberger et al · Frontiers Media S.A · 2026 · ISSN 2296-634X
The therapeutic efficacy of Mesenchymal Stromal Cells (MSCs) has been demonstrated in a multitude of pre-clinical studies and clinical trials, yet the translation of MSC therapies is limited by biological factors such as...
LCC LCC:Biology (General)Idioma eng
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Optical brain-computer interface: technological advances, clinical translation, and future perspectives
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Optical brain-computer interface: technological advances, clinical translation, and future perspectives
Ang Xuan et al · Shanghai Chinese Clinical Medicine Press Co., Ltd · 2026 · ISSN 1008-6358
Optical brain-computer interface (OBCI) represents an emerging class of neural interaction technologies that use “light” as an information carrier to enable the acquisition, decoding, and modulation of neural signals...
LCC LCC:MedicineIdioma eng
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Multi-omic and computational approaches for biomarker discovery and clinical translation in pediatric sepsis
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Multi-omic and computational approaches for biomarker discovery and clinical translation in pediatric sepsis
Logan R. Van Nynatten et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
Sepsis remains one of the most complex and lethal syndromes in pediatric critical care, driven by dysregulated and heterogeneous host responses to infection. Despite decades of biomarker research, few biomarkers have bee...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Orchestration of the tumor microenvironment by citrus flavonoids: from preclinical mechanisms to translational therapeutic
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Orchestration of the tumor microenvironment by citrus flavonoids: from preclinical mechanisms to translational therapeutic
Siyao Ma et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
Malignant lung tumors are the leading cause of cancer-related mortality worldwide, and therefore remodeling of the tumor microenvironment (TME) has become an important strategy to overcome anti-tumor therapy resistance i...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Multi-institutional perspectives on team science evaluation in clinical and translational science programs: Practices, challenges, facilitators, and future directions
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Multi-institutional perspectives on team science evaluation in clinical and translational science programs: Practices, challenges, facilitators, and future directions
Whitney A. Sweeney et al · Cambridge University Press · 2026 · ISSN 2059-8661
Team science is central to clinical and translational research; however, systematic evaluation of collaborative efforts remains inconsistent and underdeveloped. To better understand current team science evaluation practi...
LCC LCC:MedicineIdioma eng
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Plant-Derived Nanovesicles: Resolving Conceptual Confusion, Overcoming Isolation Challenges, and Advancing Translational Potential
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Plant-Derived Nanovesicles: Resolving Conceptual Confusion, Overcoming Isolation Challenges, and Advancing Translational Potential
Zhang Z et al · Dove Medical Press · 2026 · ISSN 1178-2013
Zhaoyu Zhang,1,2,* Guangyang Chen,1,3,* Kaiyuan Zheng,4,* Meifang Lin,1,2 Dali Zheng,1 Youguang Lu,1,2 Li Huang,1,3 Xiaohang Chen,1,2 Ruihuan Gan1,2 1Fujian Key Laboratory of Oral Diseases, School...
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A randomized crossover clinical trial comparing 24-h blood pressure measurements from two different cuffless wrist ambulatory monitors with cuffed ambulatory monitoring for translation to clinical practice: Rationale and Design of Continuum BP study
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A randomized crossover clinical trial comparing 24-h blood pressure measurements from two different cuffless wrist ambulatory monitors with cuffed ambulatory monitoring for translation to clinical practice: Rationale and Design of Continuum BP study
Ajay K. Gupta et al · Elsevier · 2026 · ISSN 2666-6022
Study objective: Cuffless blood pressure (BP) measuring devices have potential to improve screening, diagnosis and management of hypertension. However, translation of BP estimates from such devices to cuffed BP readings,...
LCC TENDOkRpc2Vhc2VzIG9mIHRoZSBjaXJjdWxhdG9yeSAoQ2FyZGlvdmFzY3VsYXIpIHN5c3RlbQ~~Idioma eng
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Molecular PET and immuno-PET in gastric cancer immunotherapy: current evidence, clinical utilities, and translational barriers
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Molecular PET and immuno-PET in gastric cancer immunotherapy: current evidence, clinical utilities, and translational barriers
Qiang Hu et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
This mini-review aims to examine how molecular PET and immuno-PET may complement tissue-based biomarkers in gastric cancer immunotherapy by enabling whole-body assessment of target expression, stromal biology, immune eff...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Natural supplements in breast cancer therapy: translational evidence, clinical safety, and emerging challenges
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Natural supplements in breast cancer therapy: translational evidence, clinical safety, and emerging challenges
Sirajunisa Talath et al · Frontiers Media S.A · 2026 · ISSN 2234-943X
The incidence and mortality rates of breast cancer are increasing, although improvements in traditional treatments, and it remains the most frequent cancer among women globally. The increasing demand for natural suppleme...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Mesenchymal stem/stromal cell-based therapies for autism spectrum disorder: emerging evidence and clinical prospects
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Mesenchymal stem/stromal cell-based therapies for autism spectrum disorder: emerging evidence and clinical prospects
Minghui Xu et al · BMC · 2026 · ISSN 1479-5876
Abstract Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with rising global prevalence. Current management strategies predominantly address behavioral symptoms rather than core neurobi...
LCC LCC:MedicineIdioma eng
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Precision immunotherapy for head and neck cancer: therapeutic combinations, biomarker strategies, and translational challenges
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Precision immunotherapy for head and neck cancer: therapeutic combinations, biomarker strategies, and translational challenges
Kohei Okuyama et al · BMC · 2026 · ISSN 1476-4598
Abstract Immune checkpoint inhibitors (ICIs) have fundamentally altered the therapeutic paradigm for head and neck squamous cell carcinoma (HNSCC); however, durable clinical benefit remains limited to biologically define...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Preclinical efficacy and safety evaluation of human embryonic stem cell-derived functional hepatocytes for a clinical trial in acute liver failure
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Preclinical efficacy and safety evaluation of human embryonic stem cell-derived functional hepatocytes for a clinical trial in acute liver failure
Yi Sun et al · BMC · 2026 · ISSN 1757-6512
Abstract Background Acute liver failure (ALF) is a life-threatening syndrome characterized by rapid deterioration of liver function, resulting in high mortality and posing a substantial global health burden. Human embryo...
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Navigating the Next Wave of Clinical Trials for Alzheimer’s Disease Research
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Navigating the Next Wave of Clinical Trials for Alzheimer’s Disease Research
Rachel Sudhakar · University of Ottawa · 2026 · ISSN 2292-650X
Recent advances in Alzheimer’s disease research have reshaped how clinical trials are designed and interpreted, particularly through the use of targeted monoclonal antibodies, biomarker-guided enrollment, and novel dru...
LCC LCC:Medicine; TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Normal Range and Influencing Factors of Distal Radioulnar Joint Translation: A Descriptive Study
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Normal Range and Influencing Factors of Distal Radioulnar Joint Translation: A Descriptive Study
Shijie Jia et al · Wiley · 2026 · ISSN 1757-7853
ABSTRACT Objective Distal radioulnar joint (DRUJ) instability is commonly assessed clinically via physical examination, such as a ballottement test, which evaluates palmar‐dorsal translation of the radius relative to t...
LCC TENDOk9ydGhvcGVkaWMgc3VyZ2VyeQ~~Idioma eng
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Preliminary evidence of the validity process of the Autism Diagnostic Observation Schedule (ADOS): translation, cross-cultural adaptation and semantic equivalence of the Brazilian Portuguese version
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Preliminary evidence of the validity process of the Autism Diagnostic Observation Schedule (ADOS): translation, cross-cultural adaptation and semantic equivalence of the Brazilian Portuguese version
Maria Clara Pacífico et al · Associação de Psiquiatria do Rio Grande do Sul · 2019 · ISSN 2238-0019
Abstract Objectives: To translate and back-translate the Autism Diagnostic Observation Schedule (ADOS) into Brazilian Portuguese, to assess its cross-cultural semantic equivalence, and to verify indicators of quality of...
LCC TENDOlBzeWNoaWF0cnk~Idioma eng
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Sydney Melancholia Prototype Index (SMPI): translation and cross-cultural adaptation to Brazilian Portuguese
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Sydney Melancholia Prototype Index (SMPI): translation and cross-cultural adaptation to Brazilian Portuguese
Mateus Frizzo Messinger et al · Associação de Psiquiatria do Rio Grande do Sul · 2020 · ISSN 2238-0019
Abstract Introduction Depression is possibly not a single syndrome but rather comprises several subtypes. DSM-5 proposes a melancholia specifier with phenotypic characteristics that could be associated with clinical pr...
LCC TENDOlBzeWNoaWF0cnk~Idioma eng
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A review of clinical trial radiotherapy quality assurance: value, evolution and lessons
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A review of clinical trial radiotherapy quality assurance: value, evolution and lessons
G.Le Quellenec et al · Elsevier · 2026 · ISSN 2405-6308
Background and purpose: Deviations in radiotherapy quality can significantly affect clinical trial outcomes, including overall survival. Radiotherapy quality assurance (RTQA) is a systematic process by which a RT plan is...
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Antiviral peptides as emerging therapeutic agents: a narrative review of engineering strategies, delivery innovations, and clinical perspectives
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Antiviral peptides as emerging therapeutic agents: a narrative review of engineering strategies, delivery innovations, and clinical perspectives
Maryia Bohdzel et al · Nicolaus Copernicus University in Toruń · 2026 · ISSN 2450-3118
Background. Viral infections remain a major global health threat despite advances in vaccines and antiviral drugs due to the rapid emergence of resistance and new viral pathogens. Antiviral peptides (AVPs) are promising ...
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Recent advances in application of hydrogel-based nanomaterials in breast cancer: from drug delivery, immunotherapy mechanisms to clinical applications
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Recent advances in application of hydrogel-based nanomaterials in breast cancer: from drug delivery, immunotherapy mechanisms to clinical applications
Yuanbing Xu et al · BMC · 2026 · ISSN 1477-3155
Abstract Breast cancer remains one of the most prevalent malignant tumors affecting women worldwide and continues posing a major threat to global health. Current clinical treatments include surgery, chemotherapy, radioth...
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Evolving computational paradigms for noncoding variant pathogenicity prediction
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Evolving computational paradigms for noncoding variant pathogenicity prediction
Beibei Wang et al · Frontiers Media S.A · 2026 · ISSN 2296-889X
The rapid expansion of whole-genome sequencing (WGS) has highlighted the important contribution of noncoding variants to human disease, yet their pathogenic mechanisms remain difficult to resolve. Traditional statistical...
LCC LCC:Biology (General)Idioma eng
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