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Abstract Background Thiamine (vitamin B1), a cofactor in energy metabolism and antioxidant pathways, may mitigate mitochondrial dysfunction in critical illnesses. However, its association with outcomes in acute respirato...

Abstract Background Prone positioning is recommended for patients with acute respiratory distress syndrome not only to improve oxygenation, but also to reduce lung stress, and lower mortality. The association between imp...

Background and Literature ReviewHypereosinophilic syndrome (HES) is a rare, heterogeneous group of disorders defined by persistent hypereosinophilia (>1,500 cells/µL) with eosinophil-mediated end-organ damage. Its estim...

Abstract Background Differentiating cardiogenic vs noncardiogenic causes of respiratory signs can be challenging when echocardiography is unavailable. Radiographic vertebral left atrial size (VLAS) and vertebral heart si...

Respiratory syncytial virus (RSV) and severe acute respiratory syndrome coronavirus 2 (SARS−CoV−2) represent two extremes in the outcome of antibody−based interventions. The long−acting monoclonal antibody nirsev...

Abstract Background Most households in developing countries like India are not able to afford to get the services of efficient energy for cooking and lighting. Therefore, they rely mostly on solid fuels (firewood, dung c...

ObjectivesTo characterize swallowing impairment and aspiration risk in patients recovering from acute respiratory events and to identify clinical, functional, and anatomical predictors of airway invasion with a specific ...

Abstract Heart failure (HF) and chronic obstructive pulmonary disease (COPD) frequently co-occur, complicating treatment. Concerns about respiratory complications often lead to underuse of β-blockers in this population....

BackgroundAcute respiratory distress syndrome (ARDS) secondary to severe acute pancreatitis (SAP) is associated with high mortality; however, dependable biomarkers for early risk assessment remain scarce. The lactate-to-...

Wegener’s granulomatosis (WG) is a disorder that causes necrotizing granulomatosis vasculitis particularly of the upper respiratory tract, lung and kidney. A 43-year-old male who had been treated with hemodialysis beca...

Background: Heart failure (HF) represents the terminal stage of many cardiovascular diseases. Doxorubicin (DOX) can induce HF through oxidative stress (OS), inflammation, and apoptosis. Ginkgetin (GK) has potential cardi...

It is reeported in the literatures that the incidence of sleep disorders is high (50-83 %) in hemodialysis patients, possibly resulting in poorer quality of life. This study is designed and carried out in order to evalua...

Abstract Background Retrospective studies frequently use single-time-point Berlin physiologic criteria (PaO2/FiO2 

Abstract Background The Evaluation of pimobendan in dogs with cardiomegaly caused by preclinical myxomatous mitral valve disease (EPIC) study monitored dogs with myxomatous mitral valve disease (MMVD) as they developed c...

ABSTRACT Calves are extremely dependent on colostrum intake for the acquisition of passive immunity. This study aimed to determine the occurrence of diarrhea and respiratory diseases and the impact of Failure of Passive ...

Laurence-Moon-Biedl syndrome (LMBS) is a rare autosomal recessive disease which is characterized by obesity, mental retardation, retinitis pigmentosa, polydactyly and hypogonadism. Here in we discussed a patient with LMB...

Hoyeraal-Hreidarsson syndrome (HHS) represents the most severe form of dyskeratosis congenita (DC), a telomere biology disorder caused by pathogenic variants in genes involved in telomere maintenance. DKC1 encodes dysker...

IntroductionKabuki syndrome (KS) is a rare, complex, multisystem, neurodevelopmental congenital disorder with characteristic phenotypic anomalies and pathogenic genetic variants of the KMT2D or KDM6A genes. KS is highly ...

Combined diquat and paraquat poisoning is a rare but clinically significant form of poisoning, associated with severe oxidative stress and multiorgan failure. Historical case series have reported high case fatality, part...

Objective The ROX index, combining oxygenation and respiratory rate, is widely used to assess respiratory failure. However, its prognostic value in critically ill patients with chronic obstructive pulmonary disease (COPD...

We performed a single-center retrospective analysis of chronic granulomatous disease (CGD) autopsy reports to better understand causes of death, end-organ damage, and disease pathophysiology. Forty-four autopsies of CGD ...

Next-generation metagenomic sequencing (mNGS) enables the direct and unbiased detection of pathogens from clinical samples, overcoming the limitations of standard methods. It is particularly valuable in immunocompromised...

A 54-year-old female who had been receiving continuous ambulatory peritoneal dialysis therapy for 5 years because of end-stage renal disease, was admitted to hospital because of peritonitis due to Candida albicans. Ultra...