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This review discusses organic semiconductors interfaced with biomolecular systems, focusing on the construction of material systems through biochemical pathways for device nanoarchitectonics. The initial section highligh...

En el presente trabajo se aborda un estudio cristalográfico del sitio activo de la enzima cisteínica papaína en complejo con uno de sus inhibidores. El estudio incluye el proceso de cristalización, con diferentes mé...

El Mazo rock shelter (Asturias, Spain) contains a long and well-dated Mesolithic sequence that shows an extended human presence between 9 and 7.4 ka cal BP, including the climatic 8.2 ka event. This is evident from firep...

Autosomal-dominant hyper-IgE syndrome (AD-HIES) is characterized by chronic mucocutaneous candidiasis, recurrent sinopulmonary pneumonias, noninflammatory atopic dermatitis, extremely high levels of serum IgE, and non-im...

Abstract Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. The Biobanking and Biomolecular Resources European Research Infrastructure (BBMRI-ERIC) established a CRC-Cohort with European cover...

Abstract The mechanisms by which core clock components are spatially organized to ensure robust oscillations in mammals remain unclear. Here, we identify the positive limb factor BMAL1 as a phase-separating protein that ...

Abstract Background Hyperosmotic shock and the resulting cell volume compression are commonly experienced by organs such as the kidneys, causing rapid formation of hyperosmotic phase separation (HOPS) condensates in the ...

In the search for new compounds for the treatment of Chagas disease, the cysteine protease cruzipain remains as one of the most attractive biomolecular targets for drug development. Thiosemicarbazones (TSCs) have been id...

Abstract Optical fiber sensing carries a number of potential advantages for diagnostics and biomarker detection and monitoring, yet particular challenges persist in linking molecular recognition events to a change in the...

Over the past three decades, a new picture of our own ancestral past has emerged through the elucidation of the complex genetic relationships between Neanderthals, Denisovans, and modern humans by the direct analysis of ...

Abstract Phase separation (PS) of biomolecular condensates is often assumed to be driven by interactions involving nucleic acids and intrinsically disordered regions (IDRs) of proteins. PGL-3 is a component of P granules...

The significant rise in implementation and applications of plasmonic nanosystems in biophysics, biochemistry, and medicine has culminated in the emergence of refined plasmonic enabling reagents, or “nanoagents”. Thes...

Recent advances in protein structure prediction, such as AlphaFold, have demonstrated the power of deep neural architectures like the Evoformer for capturing complex spatial and evolutionary constraints on protein confor...

Surface plasmon polaritons (SPPs) have found their key applications in high-sensitivity biomolecular detection and integrated photonic devices for optical communication via light manipulation at nanostructures. Despite t...

Surface plasmon resonance (SPR) biosensor is a powerful tool for studying the kinetics of biomolecular interactions because they offer unique real-time and label-free measurement capabilities with high detection sensitiv...

Traditional poppy vinegar is a functional fermented food matrix enriched with diverse biomolecules that may contribute to metabolic health. In this study, the effects of thermosonication on the biomolecular profile, anti...

Advances in biomolecular methods, in particular the study of ancient proteins (palaeoproteomics), have revolutionised how we can taxonomically identify archaeological bone fragments. Alongside traditional zooarchaeologic...

Estudios espectroscópicos de pequeños organofosforados (OPs) dan cuenta de la existencia de terceros confórmeros a temperatura ambiente. Estos constituyen los primeros resultados experimentales que evidencian un compo...

El presente trabajo de tesis doctoral contempla tres objetivos generales. El primero de ellos es sintetizar y estudiar las propiedades vibracionales, conformacionales y estructurales de compuestos derivados del cloruro d...

La espectroscopía de Resonancia Magnética Nuclear (RMN) ha sido durante mucho tiempo una herramienta valiosa para caracterizar las conformaciones moleculares de proteínas intrínsecamente desordenadas (IDPs), sin emba...

La Biología Molecular se dedica fundamentalmente al estudio de la estructura y funcionalidad de proteínas y ácidos nucleicos. A partir del descubrimiento de la estructura en doble hélice del ADN en 1953, el área ha...

Aquatic animals, mainly those living near farms, factories, or cities are subject to pollution caused by pesticides and/or chemicals. Since most pesticides are liposoluble and of widespread use, they affect adipose tissu...