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Abstract Heart failure (HF) is a common disease resulting in high morbidity, mortality, and healthcare costs. An important cause of HF is mitral valve regurgitation (MR), which induces left ventricular remodeling and vol...

Abstract Brain pericytes are mediators of neuroinflammation, as evidenced in vitro, in animal models and humans. We and others have identified the platelet-derived growth factor (PDGF)-BB -PDGF receptor beta (PDGFRB) pat...

Introduction: Low-voltage electrical injuries are generally considered low risk but can cause significant thermal injury when current is concentrated through conductive materials. Circumferential neck burns from mobile p...

Abstract Background DNA methylation analysis provides a promising triage strategy for cervical intraepithelial neoplasia (CIN) and cancer detection following Human Papillomavirus (HPV) testing on self-collected samples, ...

Abstract Chronic wound analysis is crucial for effective wound care, necessitating precise and efficient segmentation techniques. This study explores the use of YOLOv8 and YOLO11, renowned deep learning algorithms for ob...

Abstract This study provides a comprehensive dataset (FAIRUrbTemp) that addresses the lack of high-resolution urban air temperature data across Europe. It compiles sub-hourly street-level air temperature data from 811 lo...

Abstract Background Long COVID is an infection-associated chronic condition with uncertain evolution, leading to ambiguity in case definitions and various hypotheses about its pathophysiology. Despite this diversity, cau...

Abstract Background Endothelial cells (ECs) orchestrate vascular homeostasis and resilience but can undergo reprogramming into a mesenchymal-like phenotype through an endothelial-to-mesenchymal transition (EndMT). Crucia...

Abstract Purpose Intraoperative radiotherapy (IORT) is designed to deliver a precise dose of ionizing radiation to a tumor or tumor bed after surgical resection. The IORT procedure can deliver targeted radiation to the t...

The integration of underutilised orphan crops into food systems can reduce the reliance on major crops for global food security and support adaptation to climate change. Major crops are increasingly susceptible to climat...

Abstract Background Numerous research studies indicate that Native Hawaiian and Pacific Islander (NHPI) youth report disproportionately higher substance use rates than other ethnic groups, as well as higher adverse effec...

Abstract Introduction Idiopathic nodular glomerulosclerosis (ING) and diabetic nephropathy (DN) display (almost) identical kidney biopsy findings. Our aim was to investigate potential disparities in histology and clinica...

Abstract The Murujuga Archipelago, Western Australia, hosts over one million petroglyphs that preserve indigenous knowledge spanning 50,000 years. This globally significant and newly UNESCO-listed world heritage site is ...

Abstract Introduction Hypospadias, a congenital condition where the urethral opening is on the ventral of the penis, presents challenges in both diagnosis and treatment. Despite surgical advancements, long-term issues su...

Abstract Background Lung cancer stigma (i.e., perceived and internalized negative appraisal and devaluation associated with lung cancer) is a clinically significant psychosocial concern among individuals diagnosed with l...

Abstract Background Myeloid epithelial reproductive tyrosine kinase (MERTK) receptor is overexpressed in cancers and is associated with poor prognosis. RGX-019-MMAE, a novel humanized IgG1-MMAE antibody-drug conjugate (A...

Introduction Early open fracture management aims to minimise the risk of complications. For the most severe open fracture wounds, multiple irrigation and debridement surgeries are required to overcome severe wound contam...

Abstract Background & aims Understanding of the dynamic changes of hepatocytes, hepatic stellate cells (HSC), Kupffer cells (KC), and liver sinusoidal endothelial cells (LSEC) is critical for studying liver (patho)physio...

Abstract Background School-aged children in low and middle-resource settings often face a high burden of preventable illnesses, yet health systems typically prioritise children under five. In 2023, 1.5 million deaths oc...